Archives: Events
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Chasing an enigma: unravelling the mystery of retroviral polyproteins for potential drug development
Retroviruses and other RNA viruses translate key proteins from a single mRNA relying on translational frameshift to produce concatenating protein domains called polyproteins before subsequent cleavage during maturation to produce…
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The kidney slit diaphragm looks like a fishnet
A comprehensive understanding of the molecular architecture of the slit diaphragm (SD), a critical component of the glomerular filtration barrier, is essential in elucidating renal filtration physiology and the mechanisms…
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Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. A comprehensive structural and functional analysis of the…
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Native Mass Spectrometry as a Modern Tool for Characterizing and Drugging Transient Protein-Protein Interactions
Transient Protein-Protein Interactions (PPIs) are central mediators of protein activity and signaling network and their modulation has significant impact on cell metabolism and regulation. They are therefore considered promising, albeit…
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GCRF Sci-ART project
A collaboration between START scientists and the Keiskamma Trust (2019-2022) Jeremy Woodward, Michaela Howse & Cebo Mvubu (START PIs and Keiskamma Trust Art Project Artists) The GCRF START Sci-ART project…
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Quantum effect, biological context: An introduction to quantum biology
Quantum biology is an exciting field of research with a pronounced interdisciplinary focus. This lecture will cover a short history of quantum biology before clarifying some of the important concepts…
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Cryptic No More: Characterising a Novel Allosteric Site in the HIV-1 Protease Cantilever Region
HIV-1 protease is a critical enzyme for viral maturation and one of the most well-studied proteins in structural biology. While much attention has focused on its active site, there is…
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Structural Biology and Cancer: Using Structural Biology to Develop Immunotherapies
This talk will focus on early-stage work in the Starbird lab to investigate the structural basis for how receptor tyrosine kinases (RTKs) are activated in the context of cancer or…
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Visualizing antibody maturation for pathogenic viruses with cryo-EM
Discover how STEM-evolved monoclonal antibodies outpaced SARS-CoV-2 variants, revealed by cryo-EM structural insights.