Tag: diabetes

  • AI-Driven Structural Insights into 11β-HSD1 Inhibition: Exploring Steroidal Pregnanes for Metabolic Disease Therapeutics

    Type 2 diabetes mellitus (T2DM) remains a major global health challenge, with many patients failing to achieve optimal glycaemic control despite the availability of established therapies. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyzes the local regeneration of active cortisol, represents a promising therapeutic target for addressing the multifactorial nature of metabolic disorders. This

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  • Unwrapping insulin signalling by cryo-EM

    The atomic structure of insulin has been known since the late 1960s, but it is only relatively recently that molecular detail has been obtained of the insulin receptor and of the way in which insulin and its receptor interact and effect signal transduction into the cellular interior. These advances have been dependent both on the

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