Archives: Events
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Native Mass Spectrometry as a Modern Tool for Characterizing and Drugging Transient Protein-Protein Interactions
Transient Protein-Protein Interactions (PPIs) are central mediators of protein activity and signaling network and their modulation has significant impact on cell metabolism and regulation. They are therefore considered promising, albeit…
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GCRF Sci-ART project
A collaboration between START scientists and the Keiskamma Trust (2019-2022) Jeremy Woodward, Michaela Howse & Cebo Mvubu (START PIs and Keiskamma Trust Art Project Artists) The GCRF START Sci-ART project…
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Quantum effect, biological context: An introduction to quantum biology
Quantum biology is an exciting field of research with a pronounced interdisciplinary focus. This lecture will cover a short history of quantum biology before clarifying some of the important concepts…
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Cryptic No More: Characterising a Novel Allosteric Site in the HIV-1 Protease Cantilever Region
HIV-1 protease is a critical enzyme for viral maturation and one of the most well-studied proteins in structural biology. While much attention has focused on its active site, there is…
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Structural Biology and Cancer: Using Structural Biology to Develop Immunotherapies
This talk will focus on early-stage work in the Starbird lab to investigate the structural basis for how receptor tyrosine kinases (RTKs) are activated in the context of cancer or…
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Visualizing antibody maturation for pathogenic viruses with cryo-EM
Discover how STEM-evolved monoclonal antibodies outpaced SARS-CoV-2 variants, revealed by cryo-EM structural insights.
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Tools and technologies for cryo electron tomography
The mission of the Chan Zuckerberg Imaging Institute (CZII) is to enable deep insights into the architecture of complex biological systems at the molecular level, through the development and application…
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Development of a two-component nanoparticle vaccine displaying an HIV-1 envelope glycoprotein that elicits Tier 2 neutralising antibodies
Despite treatment and other interventions, an effective prophylactic HIV vaccine is still an essential goal in the control of HIV. Inducing robust and long-lasting antibody responses is one of the…
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Structure determination by cryoEM at 100 keV
Electron cryomicroscopy can, in principle, determine the structures of most biological molecules, but is currently limited by access, specimen preparation difficulties and cost. We present a purpose-built instrument operating at…