Archives: Events
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Tools and technologies for cryo electron tomography
The mission of the Chan Zuckerberg Imaging Institute (CZII) is to enable deep insights into the architecture of complex biological systems at the molecular level, through the development and application…
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Development of a two-component nanoparticle vaccine displaying an HIV-1 envelope glycoprotein that elicits Tier 2 neutralising antibodies
Despite treatment and other interventions, an effective prophylactic HIV vaccine is still an essential goal in the control of HIV. Inducing robust and long-lasting antibody responses is one of the…
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Structure determination by cryoEM at 100 keV
Electron cryomicroscopy can, in principle, determine the structures of most biological molecules, but is currently limited by access, specimen preparation difficulties and cost. We present a purpose-built instrument operating at…
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Cryo-EM structure of angiotensin-converting enzyme: novel structural and mechanistic insights into cooperativity, dimerization and allostery
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a critical role in blood pressure, and fluid and electrolyte homeostasis. ACE can cleave angiotensin I, bradykinin, and many other peptide…
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Supporting the adoption of cryo-EM by industry at Diamond Light Source
The electron Bio-Imaging Centre (eBIC) at Diamond Light Source offers a unique service to pharma and biotech companies to rapidly advance their discovery and development of lead compounds, biologics, or…
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Structure-guided immunogen and immunotherapeutic design
Structural biology is essential for the rational design of novel vaccines, drugs, immunotherapeutics, or other biologics. Stabilised HIV-1 envelope antigens have facilitated the discovery of rare broad and potently neutralizing…
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Unwrapping insulin signalling by cryo-EM
The atomic structure of insulin has been known since the late 1960s, but it is only relatively recently that molecular detail has been obtained of the insulin receptor and of…
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The role of single-particle cryo-EM in discovering new drugs and vaccines
Single-particle cryo-EM, in being able to capture an entire spectrum of states of a biomolecular complex, is uniquely suited for drug discovery as well as development of vaccines. Increasingly the…
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Latest cryo-EM results from South Africa
The Electron Microscope Unit (EMU) at the University of Cape Town was established over sixty years ago as a regional imaging core facility serving the needs of the biological and…