Archives: Events
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Structural Biology and Cancer: Using Structural Biology to Develop Immunotherapies
This talk will focus on early-stage work in the Starbird lab to investigate the structural basis for how receptor tyrosine kinases (RTKs) are activated in the context of cancer or…
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Visualizing antibody maturation for pathogenic viruses with cryo-EM
Discover how STEM-evolved monoclonal antibodies outpaced SARS-CoV-2 variants, revealed by cryo-EM structural insights.
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Tools and technologies for cryo electron tomography
The mission of the Chan Zuckerberg Imaging Institute (CZII) is to enable deep insights into the architecture of complex biological systems at the molecular level, through the development and application…
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Development of a two-component nanoparticle vaccine displaying an HIV-1 envelope glycoprotein that elicits Tier 2 neutralising antibodies
Despite treatment and other interventions, an effective prophylactic HIV vaccine is still an essential goal in the control of HIV. Inducing robust and long-lasting antibody responses is one of the…
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Structure determination by cryoEM at 100 keV
Electron cryomicroscopy can, in principle, determine the structures of most biological molecules, but is currently limited by access, specimen preparation difficulties and cost. We present a purpose-built instrument operating at…
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Cryo-EM structure of angiotensin-converting enzyme: novel structural and mechanistic insights into cooperativity, dimerization and allostery
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a critical role in blood pressure, and fluid and electrolyte homeostasis. ACE can cleave angiotensin I, bradykinin, and many other peptide…
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Supporting the adoption of cryo-EM by industry at Diamond Light Source
The electron Bio-Imaging Centre (eBIC) at Diamond Light Source offers a unique service to pharma and biotech companies to rapidly advance their discovery and development of lead compounds, biologics, or…
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Structure-guided immunogen and immunotherapeutic design
Structural biology is essential for the rational design of novel vaccines, drugs, immunotherapeutics, or other biologics. Stabilised HIV-1 envelope antigens have facilitated the discovery of rare broad and potently neutralizing…
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Unwrapping insulin signalling by cryo-EM
The atomic structure of insulin has been known since the late 1960s, but it is only relatively recently that molecular detail has been obtained of the insulin receptor and of…