Archives: Events
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The nitrilase mechanism: A proposal based on experimentally determined structures and molecular modeling
Nitrilases are enzymes that convert nitriles to the corresponding carboxylic acids and ammonia or to the corresponding amides. They have substantial sequence homology to the cysteine-dependent amidases, which convert amides…
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From novel DCAF1 ligands to PROTACs and chemical probes: Harnessing AI-driven technologies to target undruggable proteins
Human DCAF1 is a multidomain protein that plays a critical role in protein homeostasis. Its WDR domain functions as a substrate recruitment module for RING-type CRL4 and HECT family EDVP…
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SYRMEP beamline for Life Science: overview and applications
SYRMEP (SYnchrotron Radiation for MEdical Physics) is the hard X-ray imaging beamline of the Elettra synchrotron light source located in Trieste, Italy [1]. It is specialized in multiscale X-ray phase-contrast…
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Physics associated with the cytoskeleton – networks, motors, and confinement
The cytoskeleton in cells can play mechanical and transportation roles. Such networks, when confined, have properties that are not like that of bulk networks. We show how a self-consistent field…
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The kidney slit diaphragm looks like a fishnet
A comprehensive understanding of the molecular architecture of the slit diaphragm (SD), a critical component of the glomerular filtration barrier, is essential in elucidating renal filtration physiology and the mechanisms…
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Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. A comprehensive structural and functional analysis of the…
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Native Mass Spectrometry as a Modern Tool for Characterizing and Drugging Transient Protein-Protein Interactions
Transient Protein-Protein Interactions (PPIs) are central mediators of protein activity and signaling network and their modulation has significant impact on cell metabolism and regulation. They are therefore considered promising, albeit…
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GCRF Sci-ART project
A collaboration between START scientists and the Keiskamma Trust (2019-2022) Jeremy Woodward, Michaela Howse & Cebo Mvubu (START PIs and Keiskamma Trust Art Project Artists) The GCRF START Sci-ART project…