Archives: Events
-
From novel DCAF1 ligands to PROTACs and chemical probes: Harnessing AI-driven technologies to target undruggable proteins
Human DCAF1 is a multidomain protein that plays a critical role in protein homeostasis. Its WDR domain functions as a substrate recruitment module for RING-type CRL4 and HECT family EDVP…
-
SYRMEP beamline for Life Science: overview and applications
SYRMEP (SYnchrotron Radiation for MEdical Physics) is the hard X-ray imaging beamline of the Elettra synchrotron light source located in Trieste, Italy [1]. It is specialized in multiscale X-ray phase-contrast…
-
Physics associated with the cytoskeleton – networks, motors, and confinement
The cytoskeleton in cells can play mechanical and transportation roles. Such networks, when confined, have properties that are not like that of bulk networks. We show how a self-consistent field…
-
The kidney slit diaphragm looks like a fishnet
A comprehensive understanding of the molecular architecture of the slit diaphragm (SD), a critical component of the glomerular filtration barrier, is essential in elucidating renal filtration physiology and the mechanisms…
-
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. A comprehensive structural and functional analysis of the…
-
Native Mass Spectrometry as a Modern Tool for Characterizing and Drugging Transient Protein-Protein Interactions
Transient Protein-Protein Interactions (PPIs) are central mediators of protein activity and signaling network and their modulation has significant impact on cell metabolism and regulation. They are therefore considered promising, albeit…
-
GCRF Sci-ART project
A collaboration between START scientists and the Keiskamma Trust (2019-2022) Jeremy Woodward, Michaela Howse & Cebo Mvubu (START PIs and Keiskamma Trust Art Project Artists) The GCRF START Sci-ART project…
-
Quantum effect, biological context: An introduction to quantum biology
Quantum biology is an exciting field of research with a pronounced interdisciplinary focus. This lecture will cover a short history of quantum biology before clarifying some of the important concepts…
-
Cryptic No More: Characterising a Novel Allosteric Site in the HIV-1 Protease Cantilever Region
HIV-1 protease is a critical enzyme for viral maturation and one of the most well-studied proteins in structural biology. While much attention has focused on its active site, there is…