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Unwrapping insulin signalling by cryo-EM

19 Aug 2024 (10:10 am)

—

19 Aug 2024 (10:40 am)

Workshop Lecture or Event

cryo-EM, diabetes, insulin

Part of:

Inside the Researcher’s Mindset Congress (2024)

Venue:

Institute of Infectious Disease & Molecular Medicine

Speaker:

Prof. Michael Lawrence

The atomic structure of insulin has been known since the late 1960s, but it is only relatively recently that molecular detail has been obtained of the insulin receptor and of the way in which insulin and its receptor interact and effect signal transduction into the cellular interior. These advances have been dependent both on the use of synchrotron x-ray sources for crystallographic study and on the use of cryo-EM for single-particle reconstruction. The talk will discuss the complementary nature of these technologies in the context of these discoveries.