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Structure-guided immunogen and immunotherapeutic design

19 Aug 2024 (11:50 am)

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19 Aug 2024 (12:20 pm)

Workshop Lecture or Event

COVID, HIV, snake venom, vaccine development

Part of:

Inside the Researcher’s Mindset Congress (2024)

Venue:

Institute of Infectious Disease & Molecular Medicine

Speaker:

Dr Constantinos Kurt Wibmer

Structural biology is essential for the rational design of novel vaccines, drugs, immunotherapeutics, or other biologics. Stabilised HIV-1 envelope antigens have facilitated the discovery of rare broad and potently neutralizing antibodies, and structure-guided stabilisation of coronavirus spikes facilitated the rapid design of SARS-CoV-2 spike vaccines. Similarly, snakebite envenomation, which kills >135,000 people annually, remains a Neglected Tropical Disease, with the only effective antivenom (polyvalent animal plasma) made through outdated technology. Our work in mAb discovery and structure-guided design has impacted HIV-1 and SARS-CoV-2 vaccine development, and has led to next-generation monoclonal antivenom antibodies for the treatment of bites by African mambas and cobras.