Event Type: Talk/Lecture

  • The kidney slit diaphragm looks like a fishnet

    A comprehensive understanding of the molecular architecture of the slit diaphragm (SD), a critical component of the glomerular filtration barrier, is essential in elucidating renal filtration physiology and the mechanisms underlying kidney disease. Disruption of the SD is a hallmark of all forms of glomerulopathies, regardless of whether the cause is genetic, immunological, metabolic, or…

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  • Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas

    Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. A comprehensive structural and functional analysis of the protein P116 by single-particle cryo-electron microscopy reveals a homodimer presenting a previously unseen fold, forming a huge hydrophobic cavity, which is fully accessible to solvent.…

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