SYRMEP (SYnchrotron Radiation for MEdical Physics) is the hard X-ray imaging beamline of the Elettra synchrotron light source located in Trieste, Italy [1]. It is specialized in multiscale X-ray phase-contrast microtomography (microCT) and over the years it has been used in multifold fields. With the expected upgrade to Elettra 2.0, the new imaging station will…
A comprehensive understanding of the molecular architecture of the slit diaphragm (SD), a critical component of the glomerular filtration barrier, is essential in elucidating renal filtration physiology and the mechanisms underlying kidney disease. Disruption of the SD is a hallmark of all forms of glomerulopathies, regardless of whether the cause is genetic, immunological, metabolic, or…
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. A comprehensive structural and functional analysis of the protein P116 by single-particle cryo-electron microscopy reveals a homodimer presenting a previously unseen fold, forming a huge hydrophobic cavity, which is fully accessible to solvent.…
