Monthly Lecture
-
Cryogenic Electron Microscopy is revolutionizing biology: where are we now and the future ahead of us
Electron Microscopy under cryogenic temperatures is currently the fastest growing area in structural biology. Advances in instrumentation and software have made it possible for cryoEM to quite sustainably achieve resolutions…
-
Application of Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) for Quantitative Analysis of Biophysics Research
Spectroscopic analysis technique has attained greater traction in Biophysics research and education for quantitative detection of bulk elemental composition of a wide variety of sample like powders, solids, liquids, suspensions…
-
Monoclonal antibodies neutralizing snake venom long & short chain three finger neurotoxins
Snakebite envenomation is a neglected tropical disease killing >135,000 people annually, predominantly in developing countries. Polyvalent antivenom is the only treatment, but it’s made through outdated technology. Monoclonal antibodies (mAbs)…
-
The complex life of proteins: Folding, Trafficking, Misfolding, Aggregation and Repair
In this talk, I will review briefly the problem of protein folding, and how it may go wrong. I will then introduce broadly the cellular machines that take care of…
-
Breaking Barriers in Drug Discovery: The Fusion of Atomistic Simulation and Machine Learning in Computational Biophysics
In recent years, the field of drug design has undergone a remarkable transformation due to advancements in computer hardware and algorithms. This talk will explore how computational biophysics tools are…
-
Modelling the covalent intermediates of the nitrilase superfamily
The nitrilase superfamily, which includes amidases, are thiol enzymes that catalyze the hydrolysis and condensation of non-peptide, carbon-nitrogen linkages. The mechanism of action of these enzymes remains unknown – but…
-
Structural insights into the lysine-specific uptake mechanism for extremely low pH regulation by bacteria
Under conditions of extremely low pH, in addition to transporting lysine, the lysine-specific permease (LysP) interacts with the transcriptional regulator CadC to upregulate cadBA operon expression. cadBA encodes CadA, which…
-
Structural insights in DNA replication and repair
Structural biology has been the most successful applications of physics to biology, providing atomic information on several thousands of macromolecules and complex macromolecular machines. Among these machines, I have always…