Tag: snake venom

  • Structure-guided immunogen and immunotherapeutic design

    Structural biology is essential for the rational design of novel vaccines, drugs, immunotherapeutics, or other biologics. Stabilised HIV-1 envelope antigens have facilitated the discovery of rare broad and potently neutralizing antibodies, and structure-guided stabilisation of coronavirus spikes facilitated the rapid design of SARS-CoV-2 spike vaccines. Similarly, snakebite envenomation, which kills >135,000 people annually, remains a…

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  • Monoclonal antibodies neutralizing snake venom long & short chain three finger neurotoxins

    Snakebite envenomation is a neglected tropical disease killing >135,000 people annually, predominantly in developing countries. Polyvalent antivenom is the only treatment, but it’s made through outdated technology. Monoclonal antibodies (mAbs) are the logical alternative for developing next-generation antivenom medicines. Here, we isolated a pair of antivenom mAbs that broadly cross-neutralized long and short chain three…

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