Structural insights into the lysine-specific uptake mechanism for extremely low pH regulation by bacteria
Under conditions of extremely low pH, in addition to transporting lysine, the lysine-specific permease (LysP) interacts with the transcriptional regulator CadC to upregulate cadBA operon expression. cadBA encodes CadA, which decarboxylates lysine to cadaverine, and CadB, which exports the alkaline product (cadaverine) to the environment to reduce acidity. This process is crucial for bacterial survival…