Tag: drug discovery

  • Native Mass Spectrometry as a Modern Tool for Characterizing and Drugging Transient Protein-Protein Interactions

    Transient Protein-Protein Interactions (PPIs) are central mediators of protein activity and signaling network and their modulation has significant impact on cell metabolism and regulation. They are therefore considered promising, albeit challenging, opportunities to expand druggable chemical space. However, due to the transient nature of these interactions, this class of PPIs is particularly challenging to characterize…

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  • The role of single-particle cryo-EM in discovering new drugs and vaccines

    Single-particle cryo-EM, in being able to capture an entire spectrum of states of a biomolecular complex, is uniquely suited for drug discovery as well as development of vaccines. Increasingly the capacity of a biomolecule to “breathe” and change its structure dynamically in the thermal bath is recognized as key in understanding drug efficacy and, more…

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