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Tag: cryo-EM
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Latest cryo-EM results from South Africa
The Electron Microscope Unit (EMU) at the University of Cape Town was established over sixty years ago as a regional imaging core facility serving the needs of the biological and materials science communities. Researchers in the EMU, with help from international scientists, have established the first single-particle cryo-EM resource in Africa. We support projects ranging…
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Cryogenic electron microscopy is revolutionizing biology: where are we now and the future ahead of us
Electron Microscopy under cryogenic temperatures is currently the fastest growing area in structural biology. Advances in instrumentation and software have made it possible for cryoEM to quite sustainably achieve resolutions in the order of 3Å or better for a wide range of biological specimens, without the need of crystallization or large scale protein production. I…
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Structural insights into the lysine-specific uptake mechanism for extremely low pH regulation by bacteria
Under conditions of extremely low pH, in addition to transporting lysine, the lysine-specific permease (LysP) interacts with the transcriptional regulator CadC to upregulate cadBA operon expression. cadBA encodes CadA, which decarboxylates lysine to cadaverine, and CadB, which exports the alkaline product (cadaverine) to the environment to reduce acidity. This process is crucial for bacterial survival…