Dr Silvia Onesti

Silvia Onesti

Elettra Synchrotron, Trieste, Italy

About

Silvia Onesti obtained a PhD in Biophysics from Imperial College, working under the supervision of David Blow (one of the founders of macromolecular crystallography) and Peter Brick. After a postdoctoral fellowship at Imperial and two brief parentheses at the University of Pavia and l’École Polytechnique, she joined Imperial College as a principal investigator, where she spent 20 years first in the Department of Physics and then in the Department of Life Science. She moved back to Italy in 2009 to set up the Structural Biology Laboratory at the Italian Synchrotron facility Elettra.

Selected recent publications
1.
Cortone, G. et al. Structural and biochemical characterization of the C-terminal region of the human RTEL1 helicase. Protein Sci 33, e5093 (2024). Cite
1.
Boavida, A. et al. FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability. EMBO Rep 25, 876–901 (2024). Cite
1.
De Piante, E. et al. Exploring the G-quadruplex binding and unwinding activity of the bacterial FeS helicase DinG. Sci Rep 13, 12610 (2023). Cite
1.
Mohammed Khalid, A. A., Parisse, P., Medagli, B., Onesti, S. & Casalis, L. Atomic Force Microscopy Investigation of the Interactions between the MCM Helicase and DNA. Materials (Basel) 14, 687 (2021). Cite