Prof. Michael Lawrence

Institutions

Dept of Medical Biology, University of Melbourne

Walter and Eliza Hall Institute of Medical Research

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About

Prof. Mike Lawrence has honorary appointments within WEHI (the Walter and Eliza Hall Institute of Medical Research, Parkville Melbourne) and within the Department of Medical Biology, University of Melbourne (Parkville, Melbourne).

His undergraduate and doctoral studies were within the Department of Physics at the University of Cape Town (UCT; 1974 – 1980). He then transitioned his research into structural biology, spending two post-doctoral years at the MRC Laboratory of Molecular Biology in Cambridge, UK.

Upon return to South Africa, he worked at the SAMRC Institute of Electron Microscopy and was subsequently Director of the Electron Microscopy Unit at UCT.

He migrated to Australia in 1988 to join initially CSIRO. Since 2001, his research has centered almost entirely on the structural biology of the insulin receptor system.

Selected publications
1.
Xu, Y. et al. How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure 30, 1098-1108.e6 (2022). Cite
1.
Xiong, X. et al. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat Chem Biol 18, 511–519 (2022). Cite
1.
Menting, J. G. et al. How insulin engages its primary binding site on the insulin receptor. Nature 493, 241–245 (2013). Cite
1.
Colman, P. M. & Lawrence, M. C. The structural biology of type I viral membrane fusion. Nat Rev Mol Cell Biol 4, 309–319 (2003). Cite
1.
Lawrence, M. C. & Colman, P. M. Shape Complementarity at Protein/Protein Interfaces. Journal of Molecular Biology 234, 946–950 (1993). Cite