Prof. Joachim Frank

Institutions

Columbia University College of Physicians and Surgeons

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About

Prof. Joachim Frank is the inventor of the key underlying technology that has led to the “Resolution Revolution” in cryogenic electron microscopy (cryo-EM), a major driver of innovation in medicine, biotechnology, and agriculture.

He is a noteworthy structural biologist, and among his major works are the structure of the ribosome and calcium release channel.

In 2017, Joachim shared the Wiley Prize in Biomedical Sciences with Richard Henderson and Marin van Heel. Later in the same year he was awarded the Nobel Prize in Chemistry together with Richard Henderson and Jacques Dubochet.

He is an important innovator in the field and is currently developing techniques for time-resolved cryo-EM – making atomic-resolution movies of life processes.

Selected publications
1.
Bhattacharjee, S. et al. Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell 187, 782-796.e23 (2024). Cite
1.
Frank, J. Novel Developments in Cryo‐EM of Biological Molecules: Resolution in Time and State Space. (CRC Press, 2023). Cite
1.
Marko, M., Hsieh, C., Schalek, R., Frank, J. & Mannella, C. Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nat Methods 4, 215–217 (2007). Cite
1.
Frank, J. Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State. (Oxford University Press, 2006). Cite
1.
Electron Tomography. (Springer, New York, NY, 2006). doi:10.1007/978-0-387-69008-7. Cite
1.
Frank, J. et al. SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields. Journal of Structural Biology 116, 190–199 (1996). Cite