About
Clinton Veale received his BPharm from Rhodes University in 2007, which was followed by 2 years of clinical practice.
After completing his MSc in Medicinal and Biological chemistry at the University of Edinburgh, Clinton returned to Rhodes University to begin his PhD in Organic Chemistry under the supervision of Prof. Michael Davies-Coleman and Dr Kevin Lobb in the field of medical chemistry.
After graduating in 2014, Clint was appointed as a lecturer in Pharmaceutical Chemistry at Rhodes University. In 2015 Clinton undertook a Claude Leon Post-Doctoral Fellowship at Stellenbosch University to work with Dr Stephen Pelly.
He is currently an Associate Professor of Organic Chemistry at the University of Cape Town. Clint has a broad interest in organic chemistry, chemical biology and biophysical chemistry and its applications to drug discovery and medicinal chemistry. His current focus is the application of Native Mass Spectrometry as a tool for drugging and characterising transient Protein-Protein Interactions.
Selected publications
1485676
{1485676:3DWJ39QK},{1485676:F8SRQIMF},{1485676:YRMVDICV},{1485676:UA4H9HSV},{1485676:EGWMCXH7}
1
modern-language-association
50
date
desc
1
1
1
865
https://biophysicsworkshop.co.za/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22EGWMCXH7%22%2C%22library%22%3A%7B%22id%22%3A1485676%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veale%20and%20Edkins%22%2C%22parsedDate%22%3A%222025-05-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVeale%2C%20Clinton%20G.%20L.%2C%20and%20Adrienne%20L.%20Edkins.%20%26%23x201C%3BGenetic%20Variation%20in%20Drug%20Targets%3A%20Are%20We%20Ready%20for%20the%20Era%20of%20Precision%20Medicinal%20Chemistry%3F%26%23x201D%3B%20%26lt%3Bi%26gt%3BACS%20Medicinal%20Chemistry%20Letters%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2016%2C%20no.%205%2C%20May%202025%2C%20pp.%20706%26%23×2013%3B10%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsmedchemlett.5c00153%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsmedchemlett.5c00153%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D1485676%26amp%3Bdlkey%3D8S4QC5HI%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Genetic%20Variation%20in%20Drug%20Targets%3A%20Are%20We%20Ready%20for%20the%20Era%20of%20Precision%20Medicinal%20Chemistry%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinton%20G.%20L.%22%2C%22lastName%22%3A%22Veale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrienne%20L.%22%2C%22lastName%22%3A%22Edkins%22%7D%5D%2C%22abstractNote%22%3A%22Natural%20genetic%20variations%20profoundly%20impact%20drug%20target%20interactions%20causing%20variations%20in%20in%20vitro%20biological%20data.%20The%20overall%20occurrence%20or%20%5Cu201crare%20genetic%20variation%5Cu201d%20is%20common%20and%20enriched%20within%20population%20groups.%20Incorporating%20population-level%20genetic%20information%20earlier%20into%20the%20drug%20discovery%20pipeline%20would%20allow%20medicinal%20chemists%20to%20contribute%20to%20the%20precision%20medicine%20movement%2C%20designing%20drugs%20with%20more%20population%20relevance.%22%2C%22date%22%3A%222025-05-08%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1021%5C%2Facsmedchemlett.5c00153%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsmedchemlett.5c00153%22%2C%22collections%22%3A%5B%22EENXQ3XN%22%5D%2C%22dateModified%22%3A%222025-08-15T11%3A17%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22F8SRQIMF%22%2C%22library%22%3A%7B%22id%22%3A1485676%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veale%20and%20Clarke%22%2C%22parsedDate%22%3A%222024-07-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVeale%2C%20Clinton%20G.%20L.%2C%20and%20David%20J.%20Clarke.%20%26%23x201C%3BMass%20Spectrometry-Based%20Methods%20for%20Characterizing%20Transient%20Protein%26%23×2013%3BProtein%20Interactions.%26%23x201D%3B%20%26lt%3Bi%26gt%3BTrends%20in%20Chemistry%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%206%2C%20no.%207%2C%20July%202024%2C%20pp.%20377%26%23×2013%3B91%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.trechm.2024.05.002%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.trechm.2024.05.002%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mass%20spectrometry-based%20methods%20for%20characterizing%20transient%20protein%5Cu2013protein%20interactions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinton%20G.%20L.%22%2C%22lastName%22%3A%22Veale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Clarke%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-07-01%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.trechm.2024.05.002%22%2C%22ISSN%22%3A%222589-7209%2C%202589-5974%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.cell.com%5C%2Ftrends%5C%2Fchemistry%5C%2Fabstract%5C%2FS2589-5974%2824%2900092-3%22%2C%22collections%22%3A%5B%22EENXQ3XN%22%5D%2C%22dateModified%22%3A%222025-08-15T11%3A18%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22YRMVDICV%22%2C%22library%22%3A%7B%22id%22%3A1485676%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22L.%5Cu00a0Veale%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BL.%26%23xA0%3BVeale%2C%20Clinton%20G.%2C%20et%20al.%20%26%23x201C%3BA%20Native%20Mass%20Spectrometry%20Approach%20to%20Qualitatively%20Elucidate%20Interfacial%20Epitopes%20of%20Transient%20Protein%26%23×2013%3BProtein%20Interactions.%26%23x201D%3B%20%26lt%3Bi%26gt%3BChemical%20Communications%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2060%2C%20no.%2045%2C%202024%2C%20pp.%205844%26%23×2013%3B47%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD4CC01251H%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD4CC01251H%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D1485676%26amp%3Bdlkey%3DGQ4UK8E8%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20native%20mass%20spectrometry%20approach%20to%20qualitatively%20elucidate%20interfacial%20epitopes%20of%20transient%20protein%5Cu2013protein%20interactions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinton%20G.%22%2C%22lastName%22%3A%22L.%5Cu00a0Veale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Chakraborty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richwell%22%2C%22lastName%22%3A%22Mhlanga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Albericio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatriz%20G.%20de%20la%22%2C%22lastName%22%3A%22Torre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrienne%22%2C%22lastName%22%3A%22L.%5Cu00a0Edkins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22J.%5Cu00a0Clarke%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1039%5C%2FD4CC01251H%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.rsc.org%5C%2Fen%5C%2Fcontent%5C%2Farticlelanding%5C%2F2024%5C%2Fcc%5C%2Fd4cc01251h%22%2C%22collections%22%3A%5B%22EENXQ3XN%22%5D%2C%22dateModified%22%3A%222025-08-15T11%3A17%3A59Z%22%7D%7D%2C%7B%22key%22%3A%223DWJ39QK%22%2C%22library%22%3A%7B%22id%22%3A1485676%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kirigin%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKirigin%2C%20Elisa%2C%20et%20al.%20%26%23x201C%3BHsp70-Hsp90%20Organising%20Protein%20%28HOP%5C%2FSTIP1%29%20Is%20Required%20for%20KSHV%20Lytic%20Replication.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20General%20Virology%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%20105%2C%20no.%2011%2C%202024%2C%20p.%20002053%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjgv.0.002053%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1099%5C%2Fjgv.0.002053%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D1485676%26amp%3Bdlkey%3DWAMUBQ8M%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hsp70-Hsp90%20organising%20protein%20%28HOP%5C%2FSTIP1%29%20is%20required%20for%20KSHV%20lytic%20replication%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Kirigin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20Obinna%22%2C%22lastName%22%3A%22Okpara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorraine%22%2C%22lastName%22%3A%22Matandirotya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jamie-Lee%22%2C%22lastName%22%3A%22Ruck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederick%22%2C%22lastName%22%3A%22Weaver%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zoe%22%2C%22lastName%22%3A%22Jackson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abir%22%2C%22lastName%22%3A%22Chakraborty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinton%20Gareth%20Lancaster%22%2C%22lastName%22%3A%22Veale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Whitehouse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrienne%20Lesley%22%2C%22lastName%22%3A%22Edkins%22%7D%5D%2C%22abstractNote%22%3A%22Kaposi%5Cu2019s%20sarcoma-associated%20herpesvirus%20%28KSHV%29%20is%20a%20DNA%20virus%20that%20causes%20Kaposi%5Cu2019s%20sarcoma%2C%20a%20cancer%20of%20endothelial%20origin.%20KSHV%20uses%20the%20activity%20of%20host%20molecular%20chaperones%20like%20Hsp70%20and%20Hsp90%20for%20the%20folding%20of%20host%20and%20viral%20proteins%20required%20for%20productive%20infection.%20Hsp70%20and%20Hsp90%20chaperones%20form%20proteostasis%20networks%20with%20several%20regulatory%20proteins%20known%20as%20co-chaperones.%20Of%20these%2C%20Hsp90%5Cu2013Hsp70-organizing%20protein%20%28HOP%29%20is%20an%20early-stage%20co-chaperone%20that%20regulates%20the%20transfer%20of%20folding%20substrate%20proteins%20between%20the%20Hsp70%20and%20Hsp90%20chaperone%20systems.%20While%20the%20roles%20for%20Hsp90%20and%20Hsp70%20in%20KSHV%20biology%20have%20been%20described%2C%20HOP%20has%20not%20previously%20been%20studied%20in%20this%20context%20despite%20its%20prominent%20interaction%20with%20both%20chaperones.%20Here%2C%20we%20demonstrate%20a%20novel%20function%20for%20HOP%20as%20a%20new%20host%20factor%20required%20for%20effective%20lytic%20replication%20of%20KSHV%20in%20primary%20effusion%20cell%20lines.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1099%5C%2Fjgv.0.002053%22%2C%22ISSN%22%3A%221465-2099%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.microbiologyresearch.org%5C%2Fcontent%5C%2Fjournal%5C%2Fjgv%5C%2F10.1099%5C%2Fjgv.0.002053%22%2C%22collections%22%3A%5B%22EENXQ3XN%22%5D%2C%22dateModified%22%3A%222025-08-15T11%3A18%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22UA4H9HSV%22%2C%22library%22%3A%7B%22id%22%3A1485676%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Veale%20et%20al.%22%2C%22parsedDate%22%3A%222021-10-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BVeale%2C%20Clinton%20G.%20L.%2C%20et%20al.%20%26%23x201C%3BA%20Native%20Mass%20Spectrometry%20Platform%20Identifies%20HOP%20Inhibitors%20That%20Modulate%20the%20HSP90%26%23×2013%3BHOP%20Protein%26%23×2013%3BProtein%20Interaction.%26%23x201D%3B%20%26lt%3Bi%26gt%3BChemical%20Communications%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2057%2C%20no.%2083%2C%20Oct.%202021%2C%20pp.%2010919%26%23×2013%3B22%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1CC04257B%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1CC04257B%26lt%3B%5C%2Fa%26gt%3B.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D1485676%26amp%3Bdlkey%3DPAEW8PH5%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20native%20mass%20spectrometry%20platform%20identifies%20HOP%20inhibitors%20that%20modulate%20the%20HSP90%5Cu2013HOP%20protein%5Cu2013protein%20interaction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinton%20G.%20L.%22%2C%22lastName%22%3A%22Veale%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Mateos-Jim%5Cu00e9nez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michaelone%20C.%22%2C%22lastName%22%3A%22Vaaltyn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronel%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matodzi%20P.%22%2C%22lastName%22%3A%22Makhubu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahama%22%2C%22lastName%22%3A%22Alhassan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatriz%20G.%20de%20la%22%2C%22lastName%22%3A%22Torre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Albericio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20Logan%22%2C%22lastName%22%3A%22Mackay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrienne%20L.%22%2C%22lastName%22%3A%22Edkins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Clarke%22%7D%5D%2C%22abstractNote%22%3A%22Herein%20we%20describe%20a%20native%20mass%20spectromery%20protein%5Cu2013peptide%20model%20as%20a%20competent%20surrogate%20for%20the%20HOP%5Cu2013HSP90%20protein%5Cu2013protein%20interaction%20%28PPI%29%2C%20application%20of%20which%20led%20to%20the%20qualititive%20identification%20of%20two%20new%20peptides%20capable%20of%20in%20vitro%20PPI%20disruption.%20This%20proof%20of%20concept%20study%20offers%20a%20viable%20alternative%20for%20PPI%20inhibitor%20screening.%22%2C%22date%22%3A%222021-10-19%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1039%5C%2FD1CC04257B%22%2C%22ISSN%22%3A%221364-548X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.rsc.org%5C%2Fen%5C%2Fcontent%5C%2Farticlelanding%5C%2F2021%5C%2Fcc%5C%2Fd1cc04257b%22%2C%22collections%22%3A%5B%22EENXQ3XN%22%5D%2C%22dateModified%22%3A%222025-08-15T11%3A17%3A47Z%22%7D%7D%5D%7D
Veale, Clinton G. L., and Adrienne L. Edkins. “Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry?” ACS Medicinal Chemistry Letters, vol. 16, no. 5, May 2025, pp. 706–10, https://doi.org/10.1021/acsmedchemlett.5c00153. Download
Veale, Clinton G. L., and David J. Clarke. “Mass Spectrometry-Based Methods for Characterizing Transient Protein–Protein Interactions.” Trends in Chemistry, vol. 6, no. 7, July 2024, pp. 377–91, https://doi.org/10.1016/j.trechm.2024.05.002.
L. Veale, Clinton G., et al. “A Native Mass Spectrometry Approach to Qualitatively Elucidate Interfacial Epitopes of Transient Protein–Protein Interactions.” Chemical Communications, vol. 60, no. 45, 2024, pp. 5844–47, https://doi.org/10.1039/D4CC01251H. Download
Kirigin, Elisa, et al. “Hsp70-Hsp90 Organising Protein (HOP/STIP1) Is Required for KSHV Lytic Replication.” Journal of General Virology, vol. 105, no. 11, 2024, p. 002053, https://doi.org/10.1099/jgv.0.002053. Download
Veale, Clinton G. L., et al. “A Native Mass Spectrometry Platform Identifies HOP Inhibitors That Modulate the HSP90–HOP Protein–Protein Interaction.” Chemical Communications, vol. 57, no. 83, Oct. 2021, pp. 10919–22, https://doi.org/10.1039/D1CC04257B. Download