Physics associated with the cytoskeleton - networks, motors, and confinement | Biophysics Workshops in South Africa

Physics associated with the cytoskeleton – networks, motors, and confinement

29 Oct 2025 (4pm

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5pm)

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Abstract

The cytoskeleton in cells can play mechanical and transportation roles. Such networks, when confined, have properties that are not like that of bulk networks. We show how a self-consistent field theory approach allows the calculation of density and polarisation density profiles within a confined space, and associated prediction of mechanical properties [1]. We also contrast branching with cross-linking of filaments, where a networking theory was used for cross-linking [2]. This approach can be adapted to include dynamical remodelling of the network. Furthermore, we explore the motion of motors and so-called active cross-links in networks.

[1] S. Azote, K.K. Müller-Nedebock, European Physical Journal E, 2019, 42, 23. 

[2] N. du Toit, K.K. Müller-Nedebock, European Physical Journal E, 2025, 48, 27

Speaker

Kristian K. Müller-Nedebock

Department of Physics, Stellenbosch University

About (click to open/close)

Kristian Müller-Nedebock is professor in the Department of Physics at Stellenbosch University, South Africa. His main research specialisation is in theory of soft condensed matter physics and physics in biological systems, approached form both equilibrium and nonequilibrium perspectives. His work models the physical properties of networks of filaments, the role of polymer entanglements, and the role of active transport processes (as in molecular motors). Müller-Nedebock also has taught a broad range of physics at both undergraduate and graduate level.

Selected publications (click to open/close)

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The Biophysics in Africa Monthly Colloquium Series is a joint project of the African Light Source Foundation (AfLS), African Physical Society (AfPS), and the South African Institute of Physics (SAIP). SAIP is an adhering body of the International Union of Pure and Applied Biophysics (IUPAB). The colloquia are always on the last Wednesday of every month. In addition to participation by students and colleagues worldwide, we invite speakers from around the globe as well. For more information please feel free to contact us at colloquium.series@africanbiophysics.org