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Development of a two-component nanoparticle vaccine displaying an HIV-1 envelope glycoprotein that elicits Tier 2 neutralising antibodies

19 Aug 2024 (2:30 pm)

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19 Aug 2024 (3:00 pm)

Workshop Lecture or Event

HIV, vaccine development

Part of:

Inside the Researcher’s Mindset Congress (2024)

Venue:

Institute of Infectious Disease & Molecular Medicine

Speaker:

Dr Jeremy Woodward

Despite treatment and other interventions, an effective prophylactic HIV vaccine is still an essential goal in the control of HIV. Inducing robust and long-lasting antibody responses is one of the main targets of an HIV vaccine. Delivery of HIV Env using nanoparticle (NP) vaccines has been shown to elicit better immunogenicity than soluble HIV Env. In this talk, I describe the development of a nanoparticle-based vaccine decorated with HIV Env using the SpyCatcher/SpyTag system and its characterisation by cryo-EM. Rabbits primed with two doses of DNA vaccines and a mosaic subtype C Gag and boosted with three doses of the NPs developed autologous Tier 2 neutralising antibodies.