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The role of single-particle cryo-EM in discovering new drugs and vaccines

19 Aug 2024 (9:15 am)

—

19 Aug 2024 (10:10 am)

Workshop Lecture or Event

cryo-EM, drug design, drug discovery

Part of:

Inside the Researcher’s Mindset Congress (2024)

Venue:

Institute of Infectious Disease & Molecular Medicine

Speaker:

Prof. Joachim Frank

Single-particle cryo-EM, in being able to capture an entire spectrum of states of a biomolecular complex, is uniquely suited for drug discovery as well as development of vaccines. Increasingly the capacity of a biomolecule to “breathe” and change its structure dynamically in the thermal bath is recognized as key in understanding drug efficacy and, more generally, the propensity of its interaction with antibodies and other ligands. We anticipate that this aspect is further illuminated in the development of powerful time-resolved cryo-EM methods.