nitrilases

  • Modelling the covalent intermediates of the nitrilase superfamily

    The nitrilase superfamily, which includes amidases, are thiol enzymes that catalyze the hydrolysis and condensation of non-peptide, carbon-nitrogen linkages. The mechanism of action of these enzymes remains unknown – but substantial insight has been gained from our studies of the closely related amidases. All the enzymes have a structurally conserved active site grouping comprising two…

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