Cryo-EM structure of angiotensin-converting enzyme: novel structural and mechanistic insights into cooperativity, dimerization and allostery
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a critical role in blood pressure, and fluid and electrolyte homeostasis. ACE can cleave angiotensin I, bradykinin, and many other peptide substrates. Until recently, little was known regarding the specific role of each of the two ACE domains, their 3D structural orientation, dynamics and dimerization. In…