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CCP4 Crystallographic School in South Africa
Data Collection to Structure Refinement and Beyond
University of Cape Town, South Africa
31 March 2020 - 08 April 2020
Organizers: Trevor Sewell, Carmien Tolmie
Biophysics & Structural Biology at Synchrotrons
17-24 January 2019
This workshop is aimed at introducing young, mostly African, bioscience researchers to the power of synchrotron based facilities. It will have, as its focus, the structure determination and other biophysical resources required for vaccine design, drug discovery, industrial enzymology and agrochemicals. The course will trace the technology required to go from gene to the structure of proteins, as well as synchrotron based techniques for imaging cells. Topics covered will include advanced strategies for crystallization, high-throughput data collection by X-ray diffraction, single particle cryo-EM, structure refinement, X-ray tomography, circular dichroism and spectroscopy . Students will learn how to access synchrotron based resources and will get practical experience of working with proteins, data collection, data processing, structure interpretation and complex experimental strategies. Time has been reserved for students to collect their own data using remote access of an MX beamline at the Diamond Light Source.
Thursday: Lab Prep Work
With Ray Owens and Opher Gileadi
Friday: Crystallography and data collection
With Elspeth Garman, Gwyndaf Evans, Frank von Delft, Dave Hall, Neil Paterson and Richard Garratt
Saturday: Remote data collection, data processing, crystal mounting
With Elspeth Garman, Carmine Tolmie, the Diamond Team, Trevor Sewell, Wolf-Dieter Schubert, Mike Lawrence, et al.
Sunday: Case Studies, MR tutorial, Intro to synchrotrons
With Silvia Onesti, Mike Lawrence, Elspeth Garman, Rams Subramanian and Gwyndaf Evans
Monday: X-Ray Microscopy, NMR, CryoEM
With Eva Pereiro, Frances Separovic, Rams, and Jeremy Woodward
Tuesday and Wednesday: CryoEM
With Trevor Sewell, David Bhella, Barend Lich, et al.
With Rams, Trevor Sewell, Richard Garratt, David Bhella, Silvia Onesti, et al.
Convenor: Trevor Sewell, University of Cape Town
Co-convenor: Frances Separovic
IUPAP Support for Free Circulation of Scientists / Policy on Harassment
The CCP4 2020 workshop supports the International Union of Pure and Applied Physicists (IUPAP) Policy on Free Circulation of Scientists and the IUPAP policy statement on harassment at conferences.
Free Circulation of Scientists: The principle of the Universality of Science is fundamental to scientific progress. This principle embodies freedom of movement, association, expression and communication for scientists, as well as equitable access to data, information and research materials. In pursuing its objectives with respect to the rights and responsibilities of scientists, the International Union of Pure and Applied Physics (IUPAP) actively upholds this principle, and, in so doing, opposes any discrimination on the basis of such factors as ethnic origin, religion, citizenship, language, political stance, gender, or age. IUPAP should only sponsor conferences and events at institutions and in countries that uphold this principle. If scientists are excluded from attending IUPAP-sponsored international conferences by a host institution or country on the basis of any of these factors, IUPAP should register its concern at the highest level of that institution or country, and should not sponsor any future events in that country until such exclusions have been eliminated. [ Section 1. (http://iupap.org/sponsored-conferences/conference-policies/)]
Harrassment at Conferences: It is the policy of the International Union of Pure and Applied Physics (IUPAP) that all participants in Union, and Union-endorsed activities will enjoy an environment which encourages the free expression and exchange of scientific ideas, and is free from all forms of discrimination, harassment, and retaliation. The conference organisers will name an advisor who will consult with those who have suffered from harassment and who will suggest ways of redressing their problems, and an advisor who will counsel those accused of harassment. The conference organisers may, after due consideration, take such action they deem appropriate, including warning or expulsion from the conference without refund. [Section 4 IUPAP Conference Policies , weblink (http://iupap.org/sponsored-conferences/conference-policies/)]